This platform aims to develop specific chimeric antigen receptors (CARs) to boost the capacity of macrophages to identify and eliminate tumor cells, thus enhancing their anti-tumor effects.

This platform is dedicated to optimizing the culture conditions and techniques for macrophages, aiming to improve their activity and functional performance. Through the optimization of the culture matrix, growth factors, and overall culture conditions, the platform produces high-quality macrophages that exhibit enhanced anti-tumor capabilities.

Infecting and culturing monocytes can be highly time-consuming and challenging. This platform is designed to develop efficient techniques for rapid infection and cultivation of monocytes, thereby reducing the culture period and lowering production costs.

By optimizing the structure of viral vectors, the platform enhances transfection efficiency, addresses the challenge of transfecting macrophages, reduces MHC-I molecule levels in macrophages, protects against T-cell-mediated killing, and supports the long-term survival of CAR-M cells.